Article24 Apr 2024 One-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed many myeloma Merz and colleagues carry out solitary-cell multiomic Assessment of mononuclear cells isolated from persons obtaining BCMA-directed Vehicle T cell therapy for myeloma and demonstrate that nonresponders are characterised by an immune-suppressive microenvironment.
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With this Evaluate, Karakousi et al. offer a Doing work framework to define this position with the lymphatic technique in tumour development and present avenues for its therapeutic manipulation to boost cancer immunotherapy.
On this Overview, Jassim et al. define the varied theories which have now been proposed for cancer origins, and the determinants of cancer risk on which They are really dependent.
Longitudinal scientific tests Acquire facts on people or groups of individuals after some time, usually to view the result of a pattern, treatment, or alter.
ArticleOpen Access18 Apr 2024 An oncolytic virus providing tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy Ye and colleagues exhibit that an oncolytic virus that delivers tumor-irrelevant bystander T mobile epitopes to tumor cells can exploit the considerable population of bystander T cells during the tumor for anti-tumor immunity and potentiate cancer immunotherapy.